Fasting Blood Glucose Level Higher than Post-meal in Healthy Subjects
Abstract
Aim: The aim of the study is to make attempt to find out reasons behind higher fasting blood glucose value than postprandial blood glucose value in healthy subjects. Methods: Fasting and postprandial blood glucose was estimated in 738 subjects. The estimation was done by hexokinase method on Cobas Integra 400 plus. Results: Out of these 738 subjects of which 424 were found to have absolutely normal value whereas remaining 314 subjects were having fasting values more than postprandial glucose values. Out of these 314 only 13 were known cases of diabetes mellitus. The abnormal results were studied and some reasons were formulated for such types of results. The reason for such type of results may be the previous night diet, early morning growth hormone and cortisol surge, physiological insulin resistance where body is unable to maintain basal insulin levels during fasting, delay in gastric emptying. Apart from these, increased hepatic output and decrease peripheral utilization, stress, infection, blood pressure medication may be the possible reasons in some of the subjects. Conclusion: Fasting blood glucose levels may be higher than the post meal blood glucose in many of the healthy subjects. Such individuals may be said to have physiological insulin resistance and may develop diabetes mellitus as long term complication.
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