Study of hypoglycemic and anti-diabetic effect of grape fruit ethanolic extract on hyperglycemic glucose induced rats.
DOI:
https://doi.org/10.52981/smlj.v1i2.2724Keywords:
hypoglycemic, anti-diabetic effect, grape fruit ethanolic extract, hyperglycemicAbstract
This experiment was conducted to study the hypoglycemic and anti-diabetic effect of grape fruit ethanolic extract (outer external layer) in hyperglycemic rats induced by injection of glucose at the rate of 2g/kg body weight, after fasting 18 hours.
According to our experiment rats weighing 80-120g were used for this study. Rats were divided into 5 groups (n=6). Group I was injected 10 mg/kg body weight of glibenclamide (Daonil), this is the standard group. Group II left as control and treated with 10 mg/kg distilled water, group III was treated with 200 mg/kg body weight and group IV was treated with 400 mg/kg of ethanolic grape fruit extract. The last group (group V) was treated with 800 mg/kg of the extract. The rats in the standard group have low concentration of blood glucose after 2 hrs, 4 hrs (86.3 – 76.8 mg/dl respectively). Group III (200 mg/kg extract) have blood glucose level of 121.8 and 124.2 mg/dl respectively. Group IV (400 mg/kg) have blood glucose 147.2 and 135.7 mg/dl respectively, while the rats in last group (800 mg/kg) have the lowest level of blood glucose 90.8 and 103 mg/dl respectively which was the best group, and the blood glucose was nearly similar to that of the standard.
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