Association of expression C/C .G/G, C/G Genotypes with Glycated hemoglobin (HbA1c) levels in Sudanese children with type 1 Diabetes
الملخص
Background: Type 1 diabetes (T1D) is a common complex metabolic disease characterized by the autoimmune destruction of insulin-producing B cells of the pancreatic islets. Due to a drastic loss of B cells, resulting in no to lowinsulin production,. Genetic factors play a significant role in the aetiology of T1D, However, the main causes of morbidity and mortality today are the complications that arise from even mild hyperglycaemia in T1D cases. Glycemic control is often measured using an assay called haemoglobin A1C (HbA1c), that provides an estimate of average blood glucose in individuals over a 3month period. Aim of the study to correlate between the frequencies of C/C,G/G and C/G genotypes and HBA1C levels in T1D patients.
Objective: To evaluate the significant correlation between frequencies of genotypes and HBA1C levels.
Methods: A total of 100 Sudanese subjects with T1D were enrolled in this study, on the average age between 5 to 18 years. The study was conducted in diabetes central hospitals in Khartoum state. In order to determine the HLA gene polymorphism, the allele-specific-refractory mutation system-polymerase chain reaction (ARMS-PCR) method was utilized.
Results: There were no significant correlation (r = 0.074, P-value = 0.497) between frequencies of genotypes and HBA1C levels.
Conclusion: This study identified that there’s no significant correlation between frequencies of genotypes and HBA1C levels.
Keywords: Genotypes, Glycated hemoglobin (HbA1c), Sudanese children, type 1 Diabetes
المراجع
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22. Fizelova M, Stančáková A, Lorenzo C, Haffner SM, Cederberg H, Kuusisto J, Laakso M. Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes. The Journal of Clinical Endocrinology & Metabolism. 2015 May 1;100(5):1989-96.
23. Genuth S, Sun W, Cleary P, Gao X, Sell DR, Lachin J, DCCT/EDIC Research Group, Monnier VM. Skin advanced glycation end products glucosepane and methylglyoxalhydroimidazolone are independently associated with longterm microvascular complication progression of type 1 diabetes. Diabetes. 2015 Jan 1;64(1):266-78.
24. Thomas MR, Lip GY. Novel risk markers and risk assessments for cardiovascular disease. Circulation research.2017 Jan 6;120(1):133-49.
25. Syreeni A, Sandholm N, Cao J, Toppila I, Maahs DM, Rewers MJ, Snell-Bergeon JK, Costacou T, Orchard TJ, Caramori ML, Mauer M. Genetic determinants of glycated hemoglobin in type 1 diabetes. Diabetes. 2019 Apr 1;68(4):858-67.
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2. Dunger DB, Sperling MA, Acerini CL, Bohn DJ, Daneman D, Danne TP, Glaser NS, Hanas R, Hintz RL, Levitsky LL, Savage MO. European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents. Pediatrics. 2004 Feb;113(2):e133-40.
3. Dabelea D, Bell RA, D'Agostino Jr RB, Imperatore G, Johansen JM, Linder B, Liu LL, Loots B, Marcovina S, MayerDavis EJ, Pettitt DJ. Incidence of diabetes in youth in the United States. Jama. 2007 Jun 1;297(24):2716-24.
4. Dabelea D, Bell RA, D'Agostino Jr RB, Imperatore G, Johansen JM, Linder B, Liu LL, Loots B, Marcovina S, MayerDavis EJ, Pettitt DJ. Incidence of diabetes in youth in the United States. Jama. 2007 Jun 1;297(24):2716-24.
5. Redondo MJ, Jeffrey J, Fain PR, Eisenbarth GS, Orban T. Concordance for islet autoimmunity among monozygotic twins. New England Journal of Medicine. 2008 Dec 25;359(26):2849-50.
6. Bonifacio E, Ziegler AG. Advances in the prediction and natural history of type 1 diabetes. Endocrinology and Metabolism Clinics. 2010 Sep 1;39(3):513-25.
7. Bonifacio E, Ziegler AG. Advances in the prediction and natural history of type 1 diabetes. Endocrinology and Metabolism Clinics. 2010 Sep 1;39(3):513-25.1
8. Lambert AP, Gillespie KM, Thomson G, Cordell HJ, Todd JA, Gale EA, Bingley PJ. Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom. The Journal of Clinical Endocrinology & Metabolism. 2004 Aug 1;89(8):4037-43.
9. Horton R, Wilming L, Rand V, Lovering RC, Bruford EA, Khodiyar VK, Lush MJ, Povey S, Talbot Jr CC, Wright MW, Wain HM. Gene map of the extended human MHC. Nature Reviews Genetics. 2004 Dec 1;5(12):889-99.
10. Thomson G, Valdes AM, Noble JA, Kockum I, Grote MN, Najman J, Erlich HA, Cucca F, Pugliese A, Steenkiste A, Dorman JS. Relative predispositional effects of HLA class II DRB1‐DQB1 haplotypes and genotypes on type 1 diabetes: a meta‐analysis. Tissue antigens. 2007 Aug;70(2):110-27.
11 . Paré G, Chasman DI, Parker AN, Nathan DM, Miletich JP, Zee RY, Ridker PM. Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study. PLoS genetics. 2008 Dec 19;4(12):e1000312.
12. Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS medicine. 2017 Sep 12;14(9):e1002383.
13. Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS. Common variants at 10 genomic loci influence hemoglobin A1C levels via glycemic and nonglycemic pathways. Diabetes. 2010 Dec 1;59(12):3229-39.
14. Nathan DM, Turgeon H, Regan S. Relationship between glycated haemoglobin levels and mean glucose levels
over time. Diabetologia. 2007 Nov;50:2239-44.
15. Snieder H, Sawtell PA, Ross L, Walker J, Spector TD, Leslie RD. HbA1c levels are genetically determined even intype 1 diabetes: evidence from healthy and diabetic twins. Diabetes. 2001 Dec 1;50(12):2858-63.
16. Jacobson AM, Braffett BH, Cleary PA, Gubitosi-Klug RA, Larkin ME, DCCT/EDIC research group. The long-term effects of type 1 diabetes treatment and complications on health-related quality of life: a 23-year follow-up of the Diabetes Control and Complications / Epidemiology of Diabetes Interventions and Complications cohort. Diabetes care. 2013 Oct 1;36(10):3131-8.
17. De Boer IH, Rue TC, Cleary PA, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Brunzell JD, Diabetes Control and Complications Trial, Epidemiology of Diabetes Interventions and Complications Study Research Group. Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. Archives of internal medicine. 2011 Mar 14;171(5):412-20.
18. Genuth S, Sun W, Cleary P, Gao X, Sell DR, Lachin J, DCCT/EDIC Research Group, Monnier VM. Skin advanced glycation end products glucosepane and methylglyoxalhydroimidazolone are independently associated with longterm microvascular complication progression of type 1 diabetes. Diabetes. 2015 Jan 1;64(1):266-78.
19. Larsen ML, Hørder M, Mogensen EF. Effect of long-term monitoring of glycosylated hemoglobin levels in insulindependent diabetes mellitus. New England Journal of Medicine. 1990 Oct 11;323(15):1021-5.
20. Meigs JB, Panhuysen CI, Myers RH, Wilson PW, Cupples LA. A genome-wide scan for loci linked to plasma levels of glucose and HbA1c in a community-based sample of Caucasian pedigrees: the Framingham Offspring Study. Diabetes. 2002 Mar 1;51(3):833-40.
21. Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS. Common variants at 10 genomic loci influence hemoglobin A1C levels via glycemic and nonglycemic pathways. Diabetes. 2010 Dec 1;59(12):3229-39.
22. Fizelova M, Stančáková A, Lorenzo C, Haffner SM, Cederberg H, Kuusisto J, Laakso M. Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes. The Journal of Clinical Endocrinology & Metabolism. 2015 May 1;100(5):1989-96.
23. Genuth S, Sun W, Cleary P, Gao X, Sell DR, Lachin J, DCCT/EDIC Research Group, Monnier VM. Skin advanced glycation end products glucosepane and methylglyoxalhydroimidazolone are independently associated with longterm microvascular complication progression of type 1 diabetes. Diabetes. 2015 Jan 1;64(1):266-78.
24. Thomas MR, Lip GY. Novel risk markers and risk assessments for cardiovascular disease. Circulation research.2017 Jan 6;120(1):133-49.
25. Syreeni A, Sandholm N, Cao J, Toppila I, Maahs DM, Rewers MJ, Snell-Bergeon JK, Costacou T, Orchard TJ, Caramori ML, Mauer M. Genetic determinants of glycated hemoglobin in type 1 diabetes. Diabetes. 2019 Apr 1;68(4):858-67.
26. Good SV. Association of imputed gene expression with glycated haemoglobin (HbA1c) levels in people with type1 diabetes (Master's thesis).
منشور
2024-10-23
القسم
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